BD1060 (Redirected from BD-1060)

BD1060
Identifiers
  • N-[2-(3,4-dichlorophenyl)ethyl]-1-pyrrolidineethanamine
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC14H20Cl2N2
Molar mass287.23 g·mol−1
3D model (JSmol)
  • C1CCN(C1)CCNCCC2=CC(=C(C=C2)Cl)Cl
  • InChI=1S/C14H20Cl2N2/c15-13-4-3-12(11-14(13)16)5-6-17-7-10-18-8-1-2-9-18/h3-4,11,17H,1-2,5-10H2
  • Key:KFLJZQLENAVFAL-UHFFFAOYSA-N

BD1060 or N-[2-(3,4-dichlorophenyl)ethyl]-1-pyrrolidineethanamine is a selective sigma receptor antagonist, with a reported binding affinity of Ki = 3 ± 0.1 nM for the sigma-1 receptor and greater than 50 times selectivity over the sigma-2 receptor.

Like other sigma receptor antagonists, pretreating Swiss Webster mice with BD1060 significantly reduces the behavioral toxicity of cocaine.

See also


This page was last updated at 2023-11-29 00:44 UTC. Update now. View original page.

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