DOV-216,303

DOV-216,303
Legal status
Legal status
Identifiers
  • 1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC11H11Cl2N
Molar mass228.12 g·mol−1
3D model (JSmol)
  • C1C2C1(CNC2)C3=CC(=C(C=C3)Cl)Cl
  • InChI=1S/C11H11Cl2N/c12-9-2-1-7(3-10(9)13)11-4-8(11)5-14-6-11/h1-3,8,14H,4-6H2 ☒N
  • Key:BSMNRYCSBFHEMQ-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

DOV 216,303 is an experimental antidepressant drug originally developed by DOV Pharmaceutical and was licensed to Merck & Co. in 2004; Merck and DOV terminated their relationship in December 2006.: 12 

It is a triple reuptake inhibitor (TRI), or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It is the racemic mixture of amitifadine (DOV-21,947) and its (–)-enantiomer, DOV-102,677. Its IC50 values for SERT, NET, and DAT are Ki 14 nM, 20 nM, and 78 nM, respectively.

As of March 2008, DOV had no intention to further develop DOV-216,303 because the patent on the compound had expired.: 6 

In a mouse model, DOV-216,303 has shown the ability to promote recovery after spinal cord contusion.

See also


This page was last updated at 2024-02-10 20:47 UTC. Update now. View original page.

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