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Daniel J. Drucker

Daniel Drucker

Daniel Joshua Drucker FRS.jpg
Daniel Drucker at the Royal Society admissions day in London, July 2015
Born
Daniel Joshua Drucker

(1956-06-23) 23 June 1956 (age 65)
Montreal, Quebec, Canada
Alma materUniversity of Toronto (MD)
Awards
Scientific career
Fields
Institutions
Website

Daniel Joshua Drucker (born 23 June 1956) is a Canadian endocrinologist. A Fellow of the Royal Society, he is a professor of medicine at the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto. He is known for his research into intestinal hormones and their use in the treatment of diabetes and other metabolic diseases.

Early life and education

Drucker was born and grew up in Montreal, and then enrolled in the University of Ottawa. After graduation he moved to Toronto, where he studied medicine at the University of Toronto, graduating in 1980. He received postgraduate training (medicine and endocrinology) at Johns Hopkins Hospital (1980–81), and the University of Toronto (1980–84).

Career

Beginning in 1984, Drucker worked as a research fellow at the Massachusetts General Hospital and Harvard Medical School, studying molecular endocrinology. In 1987 he returned to Toronto, taking on the position of Assistant Professor of Medicine at the University of Toronto and working as a staff doctor.

Early in his career Drucker studied the effect of hormones in the gut on the onset and development of Type 2 diabetes. In 1996, he identified the effects that GLP-2 has on small bowel proliferation in rats. His research led to the development of two types of drugs for the treatment of the disease.

Drucker joined the staff of the Samuel Lunenfeld Research Institute at Mount Sinai Hospital in 2006. In 2008 he conducted studies aimed at the development and testing of long-acting insulin-control medication. He later studied the long-term effects of related weight-loss medicines on bowel health.

A Canada Research Chair at the University of Toronto, Drucker also developed treatments for short bowel syndrome, a disorder in which fluids are poorly absorbed after resection of the small intestine.

Awards and honours

Drucker has received many national and international awards in recognition of his research accomplishments revealing the mechanisms of action and therapeutic potential of enteroendocrine hormones. These include the Prix Galien Canada for outstanding academic research (2008), the Donald F. Steiner Award for Outstanding Diabetes Research from the University of Chicago (2007), the Clinical Investigator Award from the Endocrine Society (2009), the Claude Bernard Prize from the European Association for the Study of Diabetes (2012), the Oon International Award and Lecture from the University of Cambridge (2014), the Banting Medal for Scientific Achievement from the American Diabetes Association (2014) the Manpei Suzuki Foundation International Prize for Diabetes (2014), and the Harold Hamm International Prize for Biomedical Research in Diabetes (2019). In 2021 he was awarded the Canada Gairdner International Award.

Drucker was named an Officer of the Order of Canada in 2015. He was elected a Fellow of the Royal Society (FRS) in 2015.

Selected publications

  • Drucker, D. J.; Buse, J. B.; Taylor, K.; Kendall, D. M.; Trautmann, M.; Zhuang, D.; Porter, L. (2008). "Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: A randomised, open-label, non-inferiority study". The Lancet. 372 (9645): 1240–1250. doi:10.1016/S0140-6736(08)61206-4. PMID 18782641. S2CID 12667840.
  • Drucker, D. J.; Nauck, M. A. (2006). "The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes". The Lancet. 368 (9548): 1696–705. doi:10.1016/S0140-6736(06)69705-5. PMID 17098089. S2CID 25748028.
  • Baggio, L. L.; Drucker, D. J. (2007). "Biology of Incretins: GLP-1 and GIP". Gastroenterology. 132 (6): 2131–57. doi:10.1053/j.gastro.2007.03.054. PMID 17498508.
  • Drucker, D. J. (2006). "The biology of incretin hormones". Cell Metabolism. 3 (3): 153–65. doi:10.1016/j.cmet.2006.01.004. PMID 16517403.
  • Drucker, D. J.; Philippe, J; Mojsov, S; Chick, W. L.; Habener, J. F. (1987). "Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line". Proceedings of the National Academy of Sciences of the United States of America. 84 (10): 3434–8. doi:10.1073/pnas.84.10.3434. PMC 304885. PMID 3033647.

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