Emopamil

Emopamil
Names
IUPAC name
2-isopropyl-5-(methyl- (2-phenylethyl)amino)- 2-phenylpentanenitrile
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
KEGG
UNII
  • InChI=1S/C23H30N2/c1-20(2)23(19-24,22-13-8-5-9-14-22)16-10-17-25(3)18-15-21-11-6-4-7-12-21/h4-9,11-14,20H,10,15-18H2,1-3H3 checkY
    Key: DWAWDSVKAUWFHC-UHFFFAOYSA-N checkY
  • InChI=1/C23H30N2/c1-20(2)23(19-24,22-13-8-5-9-14-22)16-10-17-25(3)18-15-21-11-6-4-7-12-21/h4-9,11-14,20H,10,15-18H2,1-3H3
    Key: DWAWDSVKAUWFHC-UHFFFAOYAK
  • N#CC(c1ccccc1)(C(C)C)CCCN(CCc2ccccc2)C
  • CC(C)C(CCCN(C)CCC1=CC=CC=C1)(C#N)C2=CC=CC=C2
Properties
C23H30N2
Molar mass 334.50 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Emopamil is a calcium channel blocker and a high-affinity ligand of human sterol isomerase.

Structure

Emopamil's structure consists of an organic amino compound, nitrile compound and a member of two benzene rings.

Applications

Emopamil also known as EMP is a phenylalkylamine and inhibitor of 5-hydroxytryptamine 5-HT2 receptors. EMP includes a chiral quaternary carbon center, and research has indicated that its optical isomers have different biological effects. It interacts in an extracellular site of the nerve cell to inhibit calcium channel responses while other phenylalkylamines act at an intracellular site. The interaction site of emopamil suggests to its greater neuroprotective efficacy in research related to ischaemia.

See also



This page was last updated at 2023-12-23 16:45 UTC. Update now. View original page.

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