Aspirin/paracetamol/caffeine (Redirected from Excedrin)

Aspirin/paracetamol/caffeine
Combination of
AspirinNSAID
ParacetamolAnalgesic
CaffeineStimulant
Clinical data
Trade namesExcedrin, Vanquish, others
AHFS/Drugs.comMultum Consumer Information
Routes of
administration
By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
3D model (JSmol)
  • O=C(Nc1ccc(O)cc1)C.O=C(O)c1ccccc1OC(=O)C.O=C2N(c1ncn(c1C(=O)N2C)C)C
  • InChI=1S/C9H8O4.C8H10N4O2.C8H9NO2/c1-6(10)13-8-5-3-2-4-7(8)9(11)12;1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2;1-6(10)9-7-2-4-8(11)5-3-7/h2-5H,1H3,(H,11,12);4H,1-3H3;2-5,11H,1H3,(H,9,10)
  • Key:BKMBGNWZSQNIKU-UHFFFAOYSA-N

Aspirin/paracetamol/caffeine is a combination drug for the treatment of pain, especially tension headache and migraine. It contains aspirin, a non-steroidal anti-inflammatory drug; paracetamol (acetaminophen), an analgesic; and caffeine, a stimulant.

Adverse effects

The recommended dosing has a low risk profile when taken occasionally in a well hydrated state. As with all medications containing paracetamol (acetaminophen), concomitant use with alcohol carries a significant risk of hepatotoxicity. The combination of paracetamol with aspirin also creates the risk of renal papillary necrosis if large doses are taken chronically. This is because paracetamol yields a toxic metabolite that can accumulate in the kidney while aspirin works to deplete the glutathione stores necessary to oxidize it. Additionally, chronic aspirin usage is associated with increased risk of gastrointestinal bleeding.

Chemical detection

The combination of these three compounds can be detected in pharmaceutical formulations, urine and blood serum in trace quantities using electrochemical methods.

Society and culture

Brand names

The combination was first introduced as the name Triagesic in 1950 by Bristol-Myers,[citation needed] which is now Bristol Myers Squibb. The right to use the name Triagesic belongs to the Argentine company Roemmers, though it is not produced anymore.[citation needed] In 1964 it was marketed under the trade name Vanquish by Sterling Drug,[citation needed] which after a series of mergers and acquisitions became a unit of Bayer AG.

In the UK it is sold as Anadin Extra. In Germany, it is sold as dolomo, Dolopyrin AL, HA-Tabletten, Melabon K, Neuralgin, ratiopyrin, Thomapyrin Classic, Thomapyrin Intensiv, in Austria as Thomapyrin, and InfluASS, in Israel as Acamol Focus, Paramol Target and Exidol, in Romania as Antinevralgic P and Antinevralgic Forte, and in Russia, Belarus and Eastern Europe as Citramon.



This page was last updated at 2023-10-28 12:38 UTC. Update now. View original page.

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