List of EC numbers (EC 3)

This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee. The database is developed and maintained by Andrew McDonald.

EC 3.1: Acting on Ester Bonds

EC 3.1.1: Carboxylic Ester Hydrolases

*No Wikipedia article

EC 3.1.2: Thioester Hydrolases

*No Wikipedia article

EC 3.1.3: Phosphoric Monoester Hydrolases

* No Wikipedia article

EC 3.1.4: Phosphoric Diester Hydrolases

*No Wikipedia article

EC 3.1.5: Triphosphoric Monoester Hydrolases

EC 3.1.6: Sulfuric Ester Hydrolases

*No Wikipedia article

EC 3.1.7: Diphosphoric Monoester Hydrolases

*No Wikipedia article

EC 3.1.8: Phosphoric Triester Hydrolases

EC 3.1.11: Exodeoxyribonucleases Producing 5'-Phosphomonoesters

EC 3.1.13: Exoribonucleases Producing 5'-Phosphomonoesters

EC 3.1.14: Exoribonucleases Producing 3'-Phosphomonoesters

EC 3.1.15: Exonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 5'-Phosphomonoesters

EC 3.1.16: Exonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 3'-Phosphomonoesters

EC 3.1.21: Endodeoxyribonucleases Producing 5'-Phosphomonoesters

*No Wikipedia article

EC 3.1.22: Endodeoxyribonucleases Producing 3'-Phosphomonoesters

EC 3.1.23: and EC 3.1.24 now EC 3.1.21.3, EC 3.1.21.4 and EC 3.1.21.5

Deleted sub-subclasses.

EC 3.1.25: Site-Specific Endodeoxyribonucleases Specific for Altered Bases

EC 3.1.26: Endoribonucleases Producing 5'-Phosphomonoesters

EC 3.1.27: Endoribonucleases Producing 3'-Phosphomonoesters

  • EC 3.1.27.1: Now EC 4.6.1.19, ribonuclease T2, since the primary reaction is that of a lyase
  • EC 3.1.27.2: Now EC 4.6.1.22, Bacillus subtilis ribonuclease, since the reaction catalysed is that of a lyase
  • EC 3.1.27.3: Now EC 4.6.1.24, ribonuclease T1, since the primary reaction is that of a lyase
  • EC 3.1.27.4: Now EC 4.6.1.20, ribonuclease U2, since the primary reaction is that of a lyase
  • EC 3.1.27.5: Now EC 4.6.1.18, pancreatic ribonuclease.
  • EC 3.1.27.6: Now EC 4.6.1.21, Enterobacter ribonuclease, since the primary reaction is that of a lyase
  • EC 3.1.27.7: ribonuclease F
  • EC 3.1.27.8: ribonuclease V
  • EC 3.1.27.9: Now EC 4.6.1.16, tRNA-intron lyase
  • EC 3.1.27.10: Now EC 4.6.1.23, ribotoxin,

EC 3.1.30: Endoribonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 5'-Phosphomonoesters

EC 3.1.31: Endoribonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 3'-Phosphomonoesters

EC 3.2: Glycosylases

EC 3.2.1: Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds

*No Wikipedia article

EC 3.2.2: Hydrolysing N-Glycosyl Compounds

*No Wikipedia article

EC 3.2.3: Hydrolysing S-Glycosyl Compounds

Deleted sub-subclass

EC 3.3: Acting on Ether Bonds

EC 3.3.1: Thioether and trialkylsulfonium hydrolases

EC 3.3.2: Ether Hydrolases

*No Wikipedia article

EC 3.4: Acting on peptide bondsPeptidase

EC 3.4.1 α-amino acyl peptide hydrolases (discontinued)

  • EC 3.4.1.1: Now EC 3.4.11.1, leucyl aminopeptidase
  • EC 3.4.1.2: Now EC 3.4.11.2, membrane alanyl aminopeptidase
  • EC 3.4.1.3: Now EC 3.4.11.4, tripeptide aminopeptidase
  • EC 3.4.1.4: Now EC 3.4.11.5, prolyl aminopeptidase

EC 3.4.2 Peptidyl amino acid hydrolases (discontinued)

EC 3.4.3: Dipeptide hydrolases (deleted sub-subclass)

  • EC 3.4.3.1: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
  • EC 3.4.3.2: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
  • EC 3.4.3.3: Now EC 3.4.13.3, Xaa-His dipeptidase
  • EC 3.4.3.4: Now EC 3.4.13.5, Xaa-methyl-His dipeptidase
  • EC 3.4.3.5: Now EC 3.4.11.2, membrane alanyl aminopeptidase
  • EC 3.4.3.6: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
  • EC 3.4.3.7: Now EC 3.4.13.9, Xaa-Pro dipeptidase

EC 3.4.4 Peptidyl Peptide Hydrolases (discontinued)

EC 3.4.11 Aminopeptidases

EC 3.4.12 Peptidylamino-acid hydrolases or acylamino-acid hydrolases (deleted sub-subclass)

  • EC 3.4.12.1: Now EC 3.4.16.5 (carboxypeptidase C) and EC 3.4.16.6 (carboxypeptidase D)
  • EC 3.4.12.2: Now EC 3.4.17.1, carboxypeptidase A
  • EC 3.4.12.3: Now EC 3.4.17.2, carboxypeptidase B
  • EC 3.4.12.4: Now EC 3.4.16.2, lysosomal Pro-Xaa carboxypeptidase
  • EC 3.4.12.5: Now EC 3.5.1.28, N-acetylmuramoyl-L-alanine amidase
  • EC 3.4.12.6: Now EC 3.4.17.8, muramoyl-pentapeptidase carboxypeptidase
  • EC 3.4.12.7: Now EC 3.4.17.3, lysine carboxypeptidase
  • EC 3.4.12.8: Now EC 3.4.17.4, Gly-Xaa carboxypeptidase
  • EC 3.4.12.9: aspartate carboxypeptidase
  • EC 3.4.12.10: Now EC 3.4.19.9, γ-glutamyl hydrolase
  • EC 3.4.12.11: Now EC 3.4.17.6, alanine carboxypeptidase
  • EC 3.4.12.12: Now EC 3.4.16.5 (carboxypeptidase C) and EC 3.4.16.6 (carboxypeptidase D)
  • EC 3.4.12.13: γ-glutamylglutamate carboxypeptidase

EC 3.4.13 Dipeptidases

*No Wikipedia article

EC 3.4.14 Dipeptidyl peptidases and tripeptidyl peptidases

*No Wikipedia article

EC 3.4.15 Peptidyl dipeptidases

EC 3.4.16 Serine type carboxypeptidases

EC 3.4.17 Metallocarboxypeptidases

*No Wikipedia article

EC 3.4.18 Cysteine type carboxypeptidases

EC 3.4.19 Omega peptidases

*No Wikipedia article

EC 3.4.21: Serine proteases

*No Wikipedia article

EC 3.4.22 Cysteine proteases

EC 3.4.23 Aspartic endopeptidases

EC 3.4.24: Metallopeptidases

EC 3.4.25 Threonine endopeptidases

  • EC 3.4.99.7: Deleted entry: euphorbain
  • EC 3.4.99.8: Deleted entry: Gliocladium proteinase
  • EC 3.4.99.9: Deleted entry: hurain. Now considered to be EC 3.4.21.25, cucumisin
  • EC 3.4.99.10: Transferred entry: insulinase. Now EC 3.4.24.56, insulysin
  • EC 3.4.99.11: Deleted entry: Streptomyces alkalophilic keratinase
  • EC 3.4.99.12: Deleted entry: Trichophyton mentagrophytes keratinase
  • EC 3.4.99.13: Transferred entry: β-lytic proteinase (Mycobacterium sorangium). Now EC 3.4.24.32 EC 3.4.24.32, β-lytic metalloendopeptidase
  • EC 3.4.99.14: Deleted entry: mexicanain
  • EC 3.4.99.15: Deleted entry: Paecilomyces proteinase
  • EC 3.4.99.16: Deleted entry: Penicillium notatum extracellular proteinase
  • EC 3.4.99.17: Deleted entry: peptidoglycan endopeptidase
  • EC 3.4.99.18: Deleted entry: pinguinain
  • EC 3.4.99.19: Transferred entry: renin. Now EC 3.4.23.15, renin
  • EC 3.4.99.20: Deleted entry: scopulariopsis proteinase
  • EC 3.4.99.21: Deleted entry: solanain. Now considered EC 3.4.21.25, cucumisin
  • EC 3.4.99.22: Transferred entry: staphylokinase. EC 3.4.24.29, aureolysin
  • EC 3.4.99.23: Deleted entry: tabernamontanain. Now considered EC 3.4.21.25, cucumisin
  • EC 3.4.99.24: Deleted entry: Tenebrio α-proteinase
  • EC 3.4.99.25: Transferred entry: trametes acid proteinase. EC 3.4.23.21, rhizopuspepsin
  • EC 3.4.99.26: Transferred entry: urokinase. Now EC 3.4.21.68, t-plasminogen activator
  • EC 3.4.99.27: Deleted entry: Echis carinatus prothrombin-activating proteinase
  • EC 3.4.99.28: Transferred entry: Oxyuranus scutellatus prothrombin-activating proteinase. EC 3.4.21.60 EC 3.4.21.60, scutelarin
  • EC 3.4.99.29: Deleted entry: Myxobacter AL-1 proteinase I
  • EC 3.4.99.30: Transferred entry: Myxobacter AL-1 proteinase II. EC 3.4.24.20, peptidyl-Lys metalloendopeptidase
  • EC 3.4.99.31: Transferred entry: tissue endopeptidase degrading collagenase synthetic substrate. EC 3.4.24.15, thimet oligopeptidase
  • EC 3.4.99.32: Transferred entry: Armillaria mellea neutral proteinase. Now EC 3.4.24.20, peptidyl-Lys metalloendopeptidase
  • EC 3.4.99.33: Deleted entry: cathepsin R
  • EC 3.4.99.34: Deleted entry: mytilidase
  • EC 3.4.99.35: Transferred entry: premurein-leader peptidase. Now EC 3.4.23.36, signal peptidase II
  • EC 3.4.99.36: Transferred entry: leader peptidase. Now EC 3.4.21.89, signal peptidase I
  • EC 3.4.99.37: Deleted entry: RecA peptidase
  • EC 3.4.99.38: Transferred entry: pro-opiomelanotropin-converting proteinase. Now EC 3.4.23.17, pro-opiomelanocortin converting enzyme
  • EC 3.4.99.39: Deleted entry: pseudomurein endopeptidase
  • EC 3.4.99.40: Deleted entry: pro-gonadoliberin proteinase
  • EC 3.4.99.41: Transferred entry: mitochondrial processing peptidase. Now EC 3.4.24.64, mitochondrial processing peptidase
  • EC 3.4.99.42: Deleted entry: leucyllysine endopeptidase
  • EC 3.4.99.43: Transferred entry: thermopsin. Npw EC 3.4.23.42, thermopsin
  • EC 3.4.99.44: Transferred entry: pitrilysin. Now EC 3.4.24.55, pitrilysin
  • EC 3.4.99.45: Transferred entry: insulinase. Now EC 3.4.24.56, insulysin
  • EC 3.4.99.46: Transferred entry: multicatalytic endopeptidase complex. Now EC 3.4.25.1, proteasome endopeptidase complex

EC 3.5: Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1: In linear amides

*No Wikipedia article

3.5.2: In cyclic amides

*No Wikipedia article

3.5.3: In linear amidines

*No Wikipedia article

3.5.4: In cyclic amidines

*No Wikipedia article

3.5.5: In nitriles

3.5.99: In other compounds

*No Wikipedia article

EC 3.6: Acting on acid anhydrides

3.6.1: In phosphorus-containing anhydrides

*No Wikipedia article

3.6.2: In sulfonyl-containing anhydrides

3.6.3: Acting on acid anhydrides to catalyse transmembrane movement of substances

  • EC 3.6.3.1: phospholipid-translocating ATPase
  • EC 3.6.3.2: Now EC 7.2.2.14, P-type Mg2+ transporter
  • EC 3.6.3.3: Now EC 7.2.2.21, Cd2+-exporting ATPase
  • EC 3.6.3.4: Now EC 7.2.2.9, Cu2+-exporting ATPase
  • EC 3.6.3.5: Now EC 7.2.2.12, Zn2+-exporting ATPase
  • EC 3.6.3.6: Now EC 7.1.2.1, P-type H+-exporting transporter
  • EC 3.6.3.7: Now EC 7.2.2.3, P-type Na+ transporter
  • EC 3.6.3.8: Now EC 7.2.2.10, Ca2+-transporting ATPase
  • EC 3.6.3.9: Now EC 7.2.2.13, Na+/K+-exchanging ATPase
  • EC 3.6.3.10: Now EC 7.2.2.19, H+/K+-exchanging ATPase
  • EC 3.6.3.11: Cl-transporting ATPase. The activity was only ever studied in crude extracts}}, and is an artifact
  • EC 3.6.3.12: Now EC 7.2.2.6, K+-transporting ATPase
  • EC 3.6.3.13:Identical to EC 3.6.3.1, phospholipid-translocating ATPase
  • EC 3.6.3.14: Now EC 7.1.2.2, H+-transporting two-sector ATPase
  • EC 3.6.3.15: Now EC 7.2.2.1, Na+-transporting two-sector ATPase
  • EC 3.6.3.16: Now EC 7.3.2.7, arsenite-transporting ATPase
  • EC 3.6.3.17: Now covered by various ABC-type monosaccharide transporters in sub-subclass EC 7.5.2
  • EC 3.6.3.18: Now EC 7.5.2.2, ABC-type oligosaccharide transporter
  • EC 3.6.3.19: Now EC 7.5.2.1, ABC-type maltose transporter
  • EC 3.6.3.20: Now EC 7.6.2.10, glycerol-3-phosphate-transporting ATPase
  • EC 3.6.3.21: Now EC 7.4.2.1, ABC-type polar-amino-acid transporter
  • EC 3.6.3.22: Now EC 7.4.2.2, ABC-type nonpolar-amino-acid transporter
  • EC 3.6.3.23: Now EC 7.4.2.6, oligopeptide-transporting ATPase
  • EC 3.6.3.24: Now EC 7.2.2.11, nickel-transporting ATPase
  • EC 3.6.3.25: Now EC 7.3.2.3, sulfate-transporting ATPase
  • EC 3.6.3.26: Now EC 7.3.2.4, nitrate-transporting ATPase
  • EC 3.6.3.27: Now EC 7.3.2.1, ABC-type phosphate transporter
  • EC 3.6.3.28: Now EC 7.3.2.2, ABC-type phosphonate transporter
  • EC 3.6.3.29: Now EC 7.3.2.5, molybdate-transporting ATPase
  • EC 3.6.3.30: Now EC 7.2.2.7, Fe3+-transporting ATPase
  • EC 3.6.3.31: Now EC 7.6.2.11, polyamine-transporting ATPase
  • EC 3.6.3.32: Now EC 7.6.2.9, quaternary-amine-transporting ATPase
  • EC 3.6.3.33: Now EC 7.6.2.8, vitamin B12-transporting ATPase
  • EC 3.6.3.34: now recognized to be at least three separate enzymes EC 7.2.2.16, iron(III) hydroxamate ABC transporter, EC 7.2.2.17, ferric enterobactin ABC transporter, and EC 7.2.2.18, ferric citrate ABC transporter
  • EC 3.6.3.35: Now EC 7.2.2.5, manganese-transporting ATPase
  • EC 3.6.3.36: Now EC 7.6.2.7, taurine-transporting ATPase
  • EC 3.6.3.37: Now EC 7.6.2.6, guanine-transporting ATPase
  • EC 3.6.3.38: Now EC 7.6.2.12, ABC-type capsular-polysaccharide transporter
  • EC 3.6.3.39: Now EC 7.5.2.5, lipopolysaccharide-transporting ATPase
  • EC 3.6.3.40: Now EC 7.5.2.4, teichoic-acid-transporting ATPase
  • EC 3.6.3.41: Now EC 7.6.2.5, heme-transporting ATPase
  • EC 3.6.3.42: Now EC 7.5.2.3, β-glucan-transporting ATPase
  • EC 3.6.3.43: Now EC 7.4.2.5, peptide-transporting ATPase
  • EC 3.6.3.44: Now EC 7.6.2.2, ABC-type xenobiotic transporter
  • EC 3.6.3.45: Now included with EC 3.6.3.44, xenobiotic-transporting ATPase
  • EC 3.6.3.46: Now EC 7.2.2.2, ABC-type Cd2+ transporter
  • EC 3.6.3.47: Now EC 7.6.2.4, fatty-acyl-CoA-transporting ATPase
  • EC 3.6.3.48: Now EC 7.4.2.7 as α-factor-pheromone transporting ATPase
  • EC 3.6.3.49: Now EC 5.6.1.6, channel-conductance-controlling ATPase
  • EC 3.6.3.50: Now EC 7.4.2.8, protein-secreting ATPase
  • EC 3.6.3.51: Now EC 7.4.2.3, mitochondrial protein-transporting ATPase
  • EC 3.6.3.52: Now EC 7.4.2.4, chloroplast protein-transporting ATPase
  • EC 3.6.3.53: Now EC 7.2.2.15, Ag+-exporting ATPase
  • EC 3.6.3.54: Now EC 7.2.2.8, Cu+-exporting ATPase
  • EC 3.6.3.55: Now EC 7.3.2.6, tungstate-importing ATPase

3.6.4: Acting on acid anhydrides to facilitate cellular and subcellular movement

3.6.5: Acting on GTP to facilitate cellular and subcellular movement

EC 3.7: Acting on carbon-carbon bonds

EC 3.7.1: In ketonic substances

*No Wikipedia article

EC 3.8: Acting on halide bonds

EC 3.8.1: Acting on halide bonds

3.8.2: In phosphorus-halide compounds (deleted sub-subclass)

  • EC 3.8.2.1: Now EC 3.1.8.2, diisopropyl-fluorophosphatase

EC 3.9: act on phosphorus-nitrogen bonds

EC 3.9.1: Acting on phosphorus-nitrogen bonds (only sub-subclass identified to date)

*No Wikipedia article

EC 3.10: Acting on sulfur-nitrogen bonds

EC 3.10.1: Acting on sulfur-nitrogen bonds (only sub-subclass identified to date)

EC 3.11: Acting on carbon-phosphorus bonds

EC 3.11.1: Acting on carbon-phosphorus bonds (only sub-subclass identified to date)

EC 3.12: Acting on sulfur-sulfur bonds

EC 3.12.1: Acting on sulfur-sulfur bonds (only sub-subclass identified to date)

EC 3.13: Acting on carbon-sulfur bonds

EC 3.13.1: Acting on carbon-sulfur bonds (only sub-subclass identified to date)

*No Wikipedia article

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