Chemical structure of the malonate ion.

The malonate or propanedioate ion is CH
(malonic acid minus two hydrogen ions). Malonate compounds include salts and esters of malonic acid, such as

Malonate is a competitive inhibitor of the enzyme succinate dehydrogenase: malonate binds to the active site of the enzyme without reacting, and so competes with succinate, the usual substrate of the enzyme. The observation that malonate is a competitive inhibitor of succinate dehydrogenase was used to deduce the structure of the active site in that enzyme. The chemical malonate decreases cellular respiration. It resembles the substrate succinate, without a −CH2CH2− group required for dehydrogenation. [1][2]

See also


  1. ^ Potter, V. R.; Dubois, K. P. (1943). "Studies on the Mechanism of Hydrogen Transport in Animal Tissues : VI. Inhibitor Studies with Succinic Dehydrogenase". The Journal of General Physiology. 26 (4): 391–404. doi:10.1085/jgp.26.4.391. PMC 2142566. PMID 19873352.
  2. ^ Dervartanian DV, Veeger C. (November 1964). "Studies on succinate dehydrogenase. I. Spectral properties of the purified enzyme and formation of enzyme-competitive inhibitor complexes". Biochim. Biophys. Acta. 92: 233–47. doi:10.1016/0926-6569(64)90182-8. PMID 14249115.

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