SLC22A12

SLC22A12
Identifiers
Aliases	SLC22A12, solute carrier family 22 (organic anion/urate transporter), member 12, OAT4L, RST, URAT1, solute carrier family 22 member 12
External IDs	OMIM: 607096 MGI: 1195269 HomoloGene: 56442 GeneCards: SLC22A12
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,602,353 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,593,062 bp
RNA expression pattern
	Top expressed in
	kidney; ; renal cortex; ; renal medulla; ; mammary gland; ; breast; ; adipose tissue; ; liver; ; subcutaneous adipose tissue; ; rhombencephalon; ; abdominal wall;
	Top expressed in
	kidney; ; renal cortex; ; proximal tubule; ; outer renal medulla; ; proximal convoluted tubule; ; proximal straight tubule; ; distal tubule; ; hypothalamus; ; spinal ganglia; ; bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	sodium-independent organic anion transmembrane transporter activity; PDZ domain binding; inorganic anion exchanger activity; urate transmembrane transporter activity; transmembrane transporter activity;
Cellular component	integral component of plasma membrane; extracellular exosome; apical plasma membrane; membrane; plasma membrane; integral component of membrane; brush border membrane;
Biological process	sodium-independent organic anion transport; urate transport; cellular homeostasis; ion transport; urate metabolic process; transmembrane transport; organic acid transmembrane transport; inorganic anion transport; transport; organic anion transport;
	Sources:Amigo / QuickGO
Orthologs
	116085
	20521
	ENSG00000197891
	ENSMUSG00000061742
	Q96S37
	Q8CFZ5
	NM_001276326; NM_001276327; NM_144585; NM_153378
	NM_009203
	NP_001263255; NP_001263256; NP_653186; NP_700357
	NP_033229
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 22 (organic anion/cation transporter), member 12, also known as SLC22A12 and URAT1, is a protein which in humans is encoded by the SLC22A12 gene.

Function

The protein encoded by this gene is a urate transporter and urate-anion exchanger which regulates the level of urate in the blood. This protein is an integral membrane protein primarily found in kidney. Two transcript variants encoding different isoforms have been found for this gene.

Clinical significance

Numerous single nucleotide polymorphisms of this gene are significantly associated with altered (increased or decreased) reabsorption of uric acid by the kidneys. Respectively, these altered rates of reabsorption contribute to hyperuricemia and hypouricemia.

Interactions

SLC22A12 has been shown to interact with PDZK1.

Inhibition

Lesinurad and dotinurad are urate transporter inhibitors that have been approved to treat gout. Lesinurad enhances urate excretion by inhibition the tubular re-absorption. Probenecid also facilitates uric acid secretion.

SLC22A12

Function

Clinical significance

Interactions

Inhibition

See also